Pertussis

Pertussis (whooping cough) is caused by an infectious bacterial agent that results in uncontrollable coughing.

How is pertussis spread?1

Coughs

  Pertussis is spread from the respiratory droplets of an infected individual. Spread through fomites may occur, however this is rare.

Symptoms2,3

The incubation period, or the between infection and the start of symptoms, ranges from 4-21 days but is most commonly 7-10 days. Incubation period of up to 42 days have been observed.

Pertussis timeline
https://www.cdc.gov/pertussis/about/signs-symptoms.html

 

 

 

Pertussis' symptoms are severe and may last up to 12 weeks

Catarrhal Stage

During the first stage of pertussis, symptoms are similar to a common cold.

Runny Nose

Runny Nose

Fever

Mild Fever

Mild Cough

Mild Cough

Apnea

Apnea (pauses in breathing)

Paroxysmal Stage

The paroxysmal stage occurs about 1-2 weeks after symptoms begin.

Paroxysm or intense coughing fits

Paroxysm (or intense coughing fits)

Vomiting

Vomiting (during or after coughing fits)

Exhaustion

Exhaustion

Convalescent Stage

2-8 weeks after the start of infection or 1-6 weeks after paroxysmal stage, the convalescent stage begins. Symptoms, including paroxysm, subside and resolve roughly 1-2 weeks.

Complications4,5

Pertussis can lead to severe complications, especially in infants and children when compared to teens and adults.

 

Common complications in infant and children:

Death

Death

Encephalopathy

Encephalopathy (swelling in the brain)

Pneumonia

Pneumonia

Convulsions

Convulsions

Apnea

Apnea

Common complications in teens and adults

Fainting or passing out

Fainting or passing out

Fractured Ribs

Fractured Ribs

Unexpected Weight loss

Unexpected weight loss

Exhaustion

Exhaustion

  • Top
  • How is it spread?
  • Symptoms
  • Complications
  • Vaccines

Pertussis Vaccines

DTaP Iggy

Several vaccines available designed to protect individuals from Pertussis. DTaP (Diphtheria, Tetanus and acellular Pertussis) and TDaP all protect you from pertussis as well as other infectious diseases such as diphtheria.

Vaccine Safety6

Reviews of VAERS reports associated with DTaP and TDaP vaccines found the vaccines to be safe. Studies looked into some specific neurological problems or seizures and found no association between these complications and the vaccines.

If you are unsure about vaccine safety, you should always speak with your doctor about any potential risks.

 

Vaccine Effectiveness

Incidence of pertussis cases
https://www.cdc.gov/pertussis/surv-reporting.html

 

 

 

Thanks to improved hygiene and the introduction of pertussis vaccinations, yearly cases of pertussis have dropped significantly since the 1950s. Vaccines are most effective as long as individuals receive the recommended number of doses as well as regular boosters.

Communities with high rates of vaccination further benefit from herd immunity, protecting those individuals who cannot be vaccinated due to medical reasons.

Vaccine Schedules7

DTaP Vaccine Schedule

DTaP Vaccine Schedule

TDaP Vaccine Schedule

TDAP Vaccine Schedule

 

How do I know if I am protected against pertussis?

Your vaccination records are the best way of knowing if you have been vaccinated. If these records cannot be found, your doctor may perform a blood test. Speak with your doctor if you are unsure about your immune status.

Types of pertussis vaccines8

Many different manufacturers produce many different vaccines to protect from not only tetanus, but also several other infectious diseases as well.

 

Legend

Legend Diphtheria and Pertussis

 

Legend Pertussis

Legend Polio

Legend Hepatitis B

Legend HiB

DTaP Vaccines

The following vaccines protect individuals from diphtheria, tetanus, and pertussis. Some vaccines also include vaccinations for polio, Heptatitis B, and/or Hib.

Daptacel manufactured by sanofi pasteur

Name: Daptacel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis
Age Range: <7 years old
Vaccine Safety Insert

infanrix manufactured by glaxosmithkline

Name: Infanrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred:Diphtheria, tetanus, pertussis
Age Range: <7 years old
Vaccine Safety Insert

Kinrix manufactured by glaxosmithkline

Name: Kinrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Diphtheria, tetanus, pertussis, polio
Age Range: <7 years old
Vaccine Safety Insert

vaxelis manufactured by MCM Vaccine Company

Name: Vaxelis (currently unavailable in the U.S.)
Manufacturer: MCM Vaccine Company
Protections Conferred: Diphtheria, tetanus, pertussis, polio, Hepatitis B, HiB
Age Range:<7 years old
Vaccine Safety Insert

pediarix manufactured by glaxosmithkline

Name: Pediarix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Diphtheria, tetanus, pertussis, polio, Hepatitis B
Age Range: <7 years old
Vaccine Safety Insert

pentacel produced by sanofi pasteur

Name: Pentacel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis, polio, HiB
Age Range:<7 years old
Vaccine Safety Insert

quadracel manufactured by sanofi pasteur

Name: Quadracel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis, polio
Age Range:<7 years old
Vaccine Safety Insert

Tdap

Tdap vaccines protect individuals from diphtheria, tetanus, and pertussis.

Adacel manufactured by sanofi pasteur

Name: Adacel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis
Age Range:10 to 64 years old
Vaccine Safety Insert

Boostrix manufactured by sanofi pasteur

Name: Boostrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Diphtheria, tetanus, pertussis
Age Range:10 years and older
Vaccine Safety Insert

Side Effects9,10

In some cases, vaccines may cause side effects. Always speak with your doctor about concerns you may have.

injection site redness or rash

Injection site redness or rash

fever

Fever

joint or muscle stiffness

Joint or muscle stiffness

injection site pain or soreness

Injection site pain or soreness

Severe Allergic Reactions

In very rare cases, severe allergic reactions have been observed. Let your doctor know if you have ever experienced any allergic reactions to vaccines.

The Bottom Line

Pertussis is a highly contagious disease that can be particularly dangerous for children. Vaccines can prevent or lessen the symptoms of pertussis.

Sources

1. Pertussis: Causes & Transmission. Centers for Disease Control and Prevention. https://www.cdc.gov/pertussis/about/causes-transmission.html. Published 2017. Accessed May 11, 2020.

2. Pertussis: Signs & Symptoms. Centers for Disease Control and Prevention. https://www.cdc.gov/pertussis/about/signs-symptoms.html. Published 2017. Accessed May 11, 2020.

3. Whooping Cough. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/whooping-cough/symptoms-…. Published 2019. Accessed May 11, 2020.

4. Pertussis: Clinical Complications. Centers for Disease Control and Prevention. https://www.cdc.gov/pertussis/clinical/complications.html. Published 2019. Accessed May 11, 2020.

5. Postels-Multani S, Wirsing von König CH, Schmitt HJ, Bock HL, Bogaerts H. Symptoms and complications of pertussis in adults. Infection. 1995;23(3):139-142. doi:10.1007/BF01793853

6. Vaccine Safety: Diphtheria, Tetanus, and Pertussis Vaccines. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccinesafety/vaccines/dtap-tdap-vaccine.html. Published 2020. Accessed May 11, 2020.

7. Child & Adolescent Immunization Schedule. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html. Published 2020. Accessed May 11, 2020.

8. Diphtheria, Tetanus, and Whooping Cough Vaccination: What Everyone Should Know. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/vpd/dtap-tdap-td/public/index.html. Published 2020. Accessed May 11, 2020.

9. Whooping Cough (Pertussis) Vaccination. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/vpd/pertussis/index.html. Published 2019. Accessed May 11, 2020.

10. Offit PA. A Look at Each Vaccine: Diphtheria, Tetanus, and Pertussis Vaccines. Children’s Hospital of Philadelphia. https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-…. Published 2020. Accessed May 11, 2020.