Pertussis (whooping cough) is caused by an infectious bacterial agent that results in uncontrollable coughing.
How is pertussis spread?1
Pertussis is spread from the respiratory droplets of an infected individual. Spread through fomites may occur, however this is rare.
Symptoms2,3
The incubation period, or the between infection and the start of symptoms, ranges from 4-21 days but is most commonly 7-10 days. Incubation period of up to 42 days have been observed.
Pertussis' symptoms are severe and may last up to 12 weeks
Catarrhal Stage
During the first stage of pertussis, symptoms are similar to a common cold.
Runny Nose
Mild Fever
Mild Cough
Apnea (pauses in breathing)
Paroxysmal Stage
The paroxysmal stage occurs about 1-2 weeks after symptoms begin.
Paroxysm (or intense coughing fits)
Vomiting (during or after coughing fits)
Exhaustion
Convalescent Stage
2-8 weeks after the start of infection or 1-6 weeks after paroxysmal stage, the convalescent stage begins. Symptoms, including paroxysm, subside and resolve roughly 1-2 weeks.
Complications4,5
Pertussis can lead to severe complications, especially in infants and children when compared to teens and adults.
Common complications in infant and children:
Death
Encephalopathy (swelling in the brain)
Pneumonia
Convulsions
Apnea
Common complications in teens and adults
Fainting or passing out
Fractured Ribs
Unexpected weight loss
Exhaustion
- Top
- How is it spread?
- Symptoms
- Complications
- Vaccines
Pertussis Vaccines
Several vaccines available designed to protect individuals from Pertussis. DTaP (Diphtheria, Tetanus and acellular Pertussis) and TDaP all protect you from pertussis as well as other infectious diseases such as diphtheria.
Vaccine Safety6
Reviews of VAERS reports associated with DTaP and TDaP vaccines found the vaccines to be safe. Studies looked into some specific neurological problems or seizures and found no association between these complications and the vaccines.
If you are unsure about vaccine safety, you should always speak with your doctor about any potential risks.
Vaccine Effectiveness
Thanks to improved hygiene and the introduction of pertussis vaccinations, yearly cases of pertussis have dropped significantly since the 1950s. Vaccines are most effective as long as individuals receive the recommended number of doses as well as regular boosters.
Communities with high rates of vaccination further benefit from herd immunity, protecting those individuals who cannot be vaccinated due to medical reasons.
Vaccine Schedules7
DTaP Vaccine Schedule
TDaP Vaccine Schedule
How do I know if I am protected against pertussis?
Your vaccination records are the best way of knowing if you have been vaccinated. If these records cannot be found, your doctor may perform a blood test. Speak with your doctor if you are unsure about your immune status.
Types of pertussis vaccines8
Many different manufacturers produce many different vaccines to protect from not only tetanus, but also several other infectious diseases as well.
Legend
DTaP Vaccines
The following vaccines protect individuals from diphtheria, tetanus, and pertussis. Some vaccines also include vaccinations for polio, Heptatitis B, and/or Hib.
Name: Daptacel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis
Age Range: <7 years old
Vaccine Safety Insert
Name: Infanrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred:Diphtheria, tetanus, pertussis
Age Range: <7 years old
Vaccine Safety Insert
Name: Kinrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Diphtheria, tetanus, pertussis, polio
Age Range: <7 years old
Vaccine Safety Insert
Name: Vaxelis (currently unavailable in the U.S.)
Manufacturer: MCM Vaccine Company
Protections Conferred: Diphtheria, tetanus, pertussis, polio, Hepatitis B, HiB
Age Range:<7 years old
Vaccine Safety Insert
Name: Pediarix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Diphtheria, tetanus, pertussis, polio, Hepatitis B
Age Range: <7 years old
Vaccine Safety Insert
Name: Pentacel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis, polio, HiB
Age Range:<7 years old
Vaccine Safety Insert
Name: Quadracel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis, polio
Age Range:<7 years old
Vaccine Safety Insert
Tdap
Tdap vaccines protect individuals from diphtheria, tetanus, and pertussis.
Name: Adacel
Manufacturer: Sanofi Pasteur
Protections Conferred: Diphtheria, tetanus, pertussis
Age Range:10 to 64 years old
Vaccine Safety Insert
Name: Boostrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Diphtheria, tetanus, pertussis
Age Range:10 years and older
Vaccine Safety Insert
Side Effects9,10
In some cases, vaccines may cause side effects. Always speak with your doctor about concerns you may have.
Injection site redness or rash
Fever
Joint or muscle stiffness
Injection site pain or soreness
Severe Allergic Reactions
In very rare cases, severe allergic reactions have been observed. Let your doctor know if you have ever experienced any allergic reactions to vaccines.
The Bottom Line
Pertussis is a highly contagious disease that can be particularly dangerous for children. Vaccines can prevent or lessen the symptoms of pertussis.
Sources
1. Pertussis: Causes & Transmission. Centers for Disease Control and Prevention. https://www.cdc.gov/pertussis/about/causes-transmission.html. Published 2017. Accessed May 11, 2020.
2. Pertussis: Signs & Symptoms. Centers for Disease Control and Prevention. https://www.cdc.gov/pertussis/about/signs-symptoms.html. Published 2017. Accessed May 11, 2020.
3. Whooping Cough. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/whooping-cough/symptoms-…. Published 2019. Accessed May 11, 2020.
4. Pertussis: Clinical Complications. Centers for Disease Control and Prevention. https://www.cdc.gov/pertussis/clinical/complications.html. Published 2019. Accessed May 11, 2020.
5. Postels-Multani S, Wirsing von König CH, Schmitt HJ, Bock HL, Bogaerts H. Symptoms and complications of pertussis in adults. Infection. 1995;23(3):139-142. doi:10.1007/BF01793853
6. Vaccine Safety: Diphtheria, Tetanus, and Pertussis Vaccines. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccinesafety/vaccines/dtap-tdap-vaccine.html. Published 2020. Accessed May 11, 2020.
7. Child & Adolescent Immunization Schedule. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html. Published 2020. Accessed May 11, 2020.
8. Diphtheria, Tetanus, and Whooping Cough Vaccination: What Everyone Should Know. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/vpd/dtap-tdap-td/public/index.html. Published 2020. Accessed May 11, 2020.
9. Whooping Cough (Pertussis) Vaccination. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/vpd/pertussis/index.html. Published 2019. Accessed May 11, 2020.
10. Offit PA. A Look at Each Vaccine: Diphtheria, Tetanus, and Pertussis Vaccines. Children’s Hospital of Philadelphia. https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-…. Published 2020. Accessed May 11, 2020.