Hepatitis B

Hepatitis B is a virus that infects the liver and increases risk of liver failure, liver cancer, or scarring of the liver.

How is Hepatitis B spread?

Hepatitis B Transmission

Hepatitis B is spread through contact with blood or bodily fluids of an infected individual.1

Symptoms

Symptoms1 of hepatitis B can range from being mild to severe, and usually appear about 1 to 4 months after infection. Oftentimes, infected individuals will appear asymptomatic.

Fever

Fever

Weakness and fatigue

 Weakness and Fatigue

Joint Pain

 Joint Pain

Abdominal Pain

 Abdominal Pain

Dark Urine

 Dark Urine

Vomiting

 Vomiting

Acute and Chronic Hepatitis B2

Acute Hepatitis B infection: lasts less than 6 months. This will likely be cleared from the immune system and complete recovery should occur within a few months.

Chronic Hepatitis B infection: lasts 6 months or longer. At this point, your immune system cannot fight off the virus. Having a chronic infection can lead to serious complications.

Complications

Chronic Hepatitis B can lead to serious complications2, which include:

Liver Cancer

Liver Cancer

Liver Failure

Liver Failure

Cirrhosis of the liver

Cirrhosis of the liver (scarring of liver tissue)

Hepatitis B Vaccines

Hepatitis B Vaccines

There are five vaccines that can help to prevent Hepatitis B:
Engerix-B
Recombivax-B
Pediatrix
Twinrix
Heplisav-B

Hepatitis B Vaccine Safety

The Hepatitis B vaccine does not contain any live viruses, and thus cannot cause the disease. Common side effects that are associated with this vaccine (i.e. redness at injection site, mild fever, joint pain) can expected as with most medications.

Hepatitis B Vaccine Effectiveness

Figure 1.3

Hepatitis B cases between 1966 and 2013

This graph shows reported cases of Hepatitis B in the United States from 1966 to 2013. Notice how there is an overall decline of reported cases since the implementation of the vaccine in 1981.

HerdImmunity

 

 

Communities that have very high rates of vaccination further benefit from herd immunity, conferring increased protection to those unable to receive the vaccination.

Hepatitis B Vaccine Schedules

Present Vaccine schedule based on CDC recommendations4 for the Hepatitis B vaccine. Click here for more information regarding the vaccination schedule.

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How do I know if I am protected against Hepatitis B?

Your vaccination records are the best way of knowing if you have been vaccinated. If these records cannot be found, your doctor may perform a blood test. Speak with your doctor if you are unsure about your immune status.

Types of Hepatitis B Vaccines

Vaccines

 

 

 

 

 

 

 

Name: Engerix-B
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred: Hepatitis B
Age Range: administered shortly after birth
Vaccine Safety Insert

Vaccines

 

 

 

 

 

 

 

Name: Recombivax HB
Manufacturer: Merck
Protections Conferred:  Hepatitis B
Age Range:  administered shortly after birth
Vaccine Safety Insert

Vaccines

 

 

 

 

 

 

 

Name: Hepsilav
Manufacturer: Dynavax
Protections Conferred:  Hepatitis B
Age Range: 18+ yo
Vaccine Safety Insert

Vaccines

 

 

 

 

 

 

 

Name: Pediarix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred:  Diptheria, Hepatitis B, Tetanus, Pertussis, Polio
Age Range:  administered shortly after birth
Vaccine Safety Insert

Vaccines

 

 

 

 

 

 

 

Name: Twinrix
Manufacturer: GlaxoSmithKline Biologicals
Protections Conferred:  Hepatitis A and Hepatitis B
Age Range:  18+ yo
Vaccine Safety Insert

Side Effects

In some cases, vaccines may cause side effects. Always speak with your doctor about concerns you may have.

Tenderness at injection site

Injection site tenderness or soreness

Fever

Fever

Injection site rash

 Injection site rash

Severe Allergic Reactions

In very rare cases, severe allergic reactions have been observed. Let your doctor know if you have ever experienced any allergic reactions to vaccines.

Anaphylaxis

Anaphylaxis has recorded in roughly 1 out of every 1.1 million doses administered.

The Bottom Line

Chronic Hepatitis B is known to be a "silent killer" because those infected often show no symptoms, and early screening tests can show normal results. By the time symptoms do appear, finding an effective treatment is unlikely. Therefore, it is important for children and adults to be vaccinated against this disease so as to decrease the risk of having liver complications.

Sources

1. Vaccine Information Statement. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/hep-b.html. Published April 5, 2019. Accessed May 4, 2020.

2. Hepatitis B. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/hepatitis-b/symptoms-cau…. Published October 27, 2017. Accessed May 4, 2020.

3. Hepatitis B - Vaccines - ProCon.org. Vaccines. https://vaccines.procon.org/vaccine-histories-and-impact/hepatitis-b/. Accessed May 4, 2020.

4. Birth-18 Years Immunization Schedule. Centers for Disease Control and Prevention. https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html?CD…. Published February 3, 2020. Accessed May 4, 2020.